NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Institute of Medicine (US) Committee on the Children's Vaccine Initiative: Planning Alternative Strategies; Mitchell VS, Philipose NM, Sanford JP, editors. The Children's Vaccine Initiative: Achieving the Vision. Washington (DC): National Academies Press (US); 1993.
The Children's Vaccine Initiative: Achieving the Vision.
Show detailsTABLE H-1Vaccine Product License Holders in the United States
| Company and Vaccine or Product | Date of License | Date of Revocation |
|---|---|---|
| Bionetics Research Inc.a | ||
| BCG vaccine | 05/29/1987 | 06/21/1989 |
| Connaught Laboratories, Inc.b | ||
| BCG live | 05/21/1990 | |
| BCG vaccine | 03/31/1967 | 05/21/1990 |
| Diphtheria & tetanus toxoids & acellular pertussis vaccine, adsorbed | 09/20/1992 | |
| Diphtheria & tetanus toxoids & pertussis vaccine (DTP) | 01/03/1978 | 11/29/1982 |
| Diphtheria & tetanus toxoids, & pertussis vaccine, adsorbed | 01/03/1978 | |
| Diphtheria & tetanus toxoids adsorbed | 09/18/1984 | |
| Diphtheria toxoid | 01/03/1978 | |
| Haemophilus influenzae type b Conjugate | ||
| (diphtheria toxoid conjugate) | 12/22/1987 | |
| Haemophilus influenzae type b polysaccharide | 12/20/1985 | |
| Influenza | 01/03/1978 | |
| Meningococcal polysaccharide group A | 01/03/1978 | |
| Meningococcal polysaccharide group C | 01/03/1978 | |
| Meningococcal polysaccharide vaccine, groups A and C combined | 01/03/1978 | |
| Meningococcal polysaccharide vaccine, groups A, C, Y, W135 combined | 11/23/1981 | |
| Pertussis vaccine | 01/03/1978 | |
| Poliomyelitis virus, inactivated human diploid cell | 11/20/1987 | |
| Poliomyelitis virus, inactivated monkey kidney cell | 01/24/1963 | |
| Rabies vaccine | 12/27/1991 | |
| Smallpox vaccine | 01/03/1978 | |
| Tetanus toxoid | 01/03/1978 | |
| Tetanus toxoid, adsorbed | 01/03/1978 | |
| Tetanus & diphtheria toxoids adsorbed (for adult use) | 01/03/1978 | |
| Yellow fever | 01/03/1978 | |
| Connaught Laboratories, Limitedb | ||
| Diphtheria toxoid | 04/28/1928 | 05/27/1977 |
| Tetanus toxoid | 01/14/1943 | |
| Small pox vaccine | 10/23/1967 | 04/01/1980 |
| Dow Chemical Companya | ||
| Diphtheria & tetanus toxoids & pertussis vaccine adsorbed | 09/11/1970 | 06/07/1977 |
| Diphtheria toxoid | 09/18/1934 | 06/07/1977 |
| DT, adsorbed | 09/11/1970 | 06/07/1977 |
| DP, adsorbed | 09/11/1970 | 06/07/1977 |
| Measles, live | 02/05/1965 | 06/07/1978 |
| Measles and rubella, live | 04/17/1974 | 06/21/1978 |
| Measles, mumps, rubella, live | 04/17/1974 | 06/21/1978 |
| Mumps virus vaccine, live | 04/17/1974 | 06/21/1978 |
| Pertussis vaccine | 10/01/1932 | 06/07/1977 |
| Rubella virus, live | 03/01/1974 | 06/21/1978 |
| Tetanus toxoid | 08/01/1936 | 06/07/1977 |
| Tetanus toxoid, adsorbed | 09/01/1970 | 06/07/1977 |
| Eli Lilly and Companya | ||
| Cholera | 10/31/1917 | 06/07/1979 |
| Diphtheria & tetanus toxoids | 09/09/1970 | 06/07/1979 |
| Diphtheria & tetanus toxoids, and pertussis vaccine adsorbed | 09/09/1970 | 12/02/1985 |
| DT, adsorbed | 09/09/1970 | 06/07/1979 |
| Influenza | 11/09/1945 | 04/11/1977 |
| Mumps vaccine | 01/27/1950 | 04/11/1977 |
| Pertussis vaccine | 03/31/1915 | 03/07/1978 |
| Rabies vaccine | 06/07/1915 | 08/11/1982 |
| Streptococcus vaccine | 04/17/1952 | 10/27/1988 |
| Tetanus toxoid | 12/10/1935 | 06/07/1979 |
| Tetanus toxoid, adsorbed | 09/09/1970 | 06/07/1979 |
| Tetanus & diphtheria toxoid adsorbed (for adult use) | 09/09/1970 | 06/07/1979 |
| Typhoid | 02/04/1954 | 11/13/1978 |
| Typhus | 03/11/1941 | 06/07/1979 |
| Evans Medical Ltd.c | ||
| Influenza | 08/12/1988 | |
| Glaxo Operations, U.K. Ltd.a | ||
| BCG vaccine | 01/24/1963 | 07/17/1990 |
| Lederle Laboratories,d | ||
| American Cyanamid Company | ||
| Cholera | 12/26/1941 | |
| Diphtheria & tetanus toxoids and acellular pertussis, adsorbed | 12/17/1991 | |
| Diphtheria & tetanus toxoids and pertussis vaccine adsorbed | 07/24/1970 | |
| DT, adsorbed | 07/29/1970 | |
| Haemophilus influenzae type b polysaccharide vaccine | 12/20/1985 | |
| Influenza | 12/07/1945 | |
| Measles virus, live | 05/03/1966 | 05/21/1980 |
| Mumps vaccine | 06/22/1950 | 05/24/1978 |
| Pertussis vaccine | 01/19/1914 | 05/29/1980 |
| Pneumococcal vaccine, polyvalent | 08/15/1979 | |
| Polio virus, live, oral trivalent | 06/25/1963 | |
| Polio virus, oral, type 1 | 03/27/1962 | |
| Polio virus, oral, type 2 | 03/27/1962 | |
| Polio virus, oral, type 3 | 03/27/1962 | |
| Rocky mountain spotted fever | 04/13/1942 | 06/11/1979 |
| Small pox | 03/01/1937 | 05/24/1978 |
| Tetanus toxoid | 06/15/1935 | |
| Tetanus toxoid, adsorbed | 07/29/1970 | |
| Tetanus & Diphtheria toxoids adsorbed (for adult use) | 07/29/1970 | |
| Typhus | 05/24/1967 | 11/20/1980 |
| Massachusetts Public Health Biologic Laboratories | ||
| Diphtheria & tetanus toxoids & pertussis vaccine adsorbed | 07/27/1970 | |
| Diphtheria toxoid | 07/07/1932 | 05/19/1980 |
| DT, adsorbed | 07/27/1970 | |
| Small pox | 03/20/1917 | 12/22/1976 |
| Tetanus toxoid | 05/16/1949 | 10/11/1989 |
| Tetanus toxoid, adsorbed | 07/29/1970 | |
| Tetanus & diphtheria toxoids adsorbed (for adult use) | 07/27/1970 | |
| Typhoid | 03/20/1917 | 10/26/1988 |
| Merck and Company | ||
| Cholera | 05/04/1952 | 01/31/1986 |
| Diphtheria & tetanus toxoids and pertussis vaccine adsorbed | 08/31/1970 | 01/31/1986 |
| Haemophilus influenzae type b conjugate (meningococcal protein conjugate) | 2/20/1989 | |
| Hepatitis B vaccine | 11/16/1981 | |
| Hepatitis B recombinant | 07/23/1986 | |
| Influenza | 11/30/1945 | |
| Measles, live and small pox | 11/17/1967 | 05/12/1987 |
| Measles virus, live | 03/21/1963 | |
| Measles and mumps virus, live | 07/18/1973 | |
| Measles and rubella virus, live | 04/22/1971 | |
| Measles, mumps, rubella, live | 04/22/1971 | |
| Meningococcal polysaccharide A | 07/11/1975 | |
| Meningococcal polysaccharide C | 04/02/1974 | |
| Meningococcal polysaccharide A&C | 10/06/1975 | |
| Meningococcal polysaccharide A. C, Y, W135 combined | 12/14/1982 | |
| Mumps virus, live | 12/28/1967 | |
| Pneumococcal | 11/21/1977 | |
| Poliomyelitis, inactivated monkey kidney cell | 04/12/1955 | 07/29/1980 |
| Rubella virus, live | 06/09/1969 | |
| Rubella and mumps, live | 08/30/1970 | |
| Small pox | 09/21/1965 | 07/29/1980 |
| Tetanus toxoid | 12/11/1933 | 01/31/1986 |
| Tetanus toxoid, adsorbed | 08/31/1970 | 01/31/1986 |
| Tetanus & diphtheria toxoids adsorbed (for adult use) | 08/31/1970 | 01/31/1986 |
| Typhoid | 04/25/1963 | 01/31/1986 |
| Typhus | 12/24/1941 | 07/29/1980 |
| Merrell-National Laboratories, Division of Richardson Merrella | ||
| Cholera | 02/27/1942 | 03/25/1976 |
| DTP | 10/15/1970 | 01/03/1978 |
| Diphtheria & tetanus toxoids & pertussis vaccine adsorbed | 05/16/1949 | 01/03/1978 |
| Diphtheria toxoid | 09/28/1929 | 01/03/1978 |
| Influenza | 09/16/1947 | 01/03/1978 |
| Meningococcal polysaccharide group A | 09/19/1975 | 01/03/1978 |
| Meningococcal polysaccharide group C | 07/11/1975 | 01/03/1978 |
| Meningococcal polysaccharide vaccine, groups A and C, combined | 09/13/1976 | 01/03/1978 |
| Pertussis vaccine | 11/16/1926 | 01/03/1978 |
| Small pox | 03/05/1937 | 01/03/1978 |
| Tetanus toxoid | 05/25/1934 | 01/03/1978 |
| Tetanus toxoid, adsorbed | 10/15/1970 | 01/03/1978 |
| Tetanus and diphtheria toxoids adsorbed (for adult use) | 03/07/1955 | 01/03/1978 |
| Yellow fever | 05/22/1953 | 01/03/1978 |
| Michigan Department of Public Health | ||
| Anthrax | 11/04/1970 | |
| Diphtheria & tetanus toxoids and pertussis vaccine adsorbed | 08/27/1970 | |
| DT, adsorbed | 08/27/1970 | |
| Pertussis vaccine | 11/22/1935 | 02/03/1977 |
| Pertussis vaccine, adsorbed | 10/12/1967 | |
| Rabies vaccine, adsorbed | 03/18/1988 | |
| Smallpox | 03/03/1937 | 06/25/1985 |
| Tetanus toxoid, adsorbed | 08/27/1970 | |
| Typhoid | 07/26/1926 | 06/25/1985 |
| Miles Inc.e | ||
| Cholera | 10/03/1968 | 10/30/1970 |
| Diphtheria and tetanus toxoids | 06/01/1951 | 10/30/1970 |
| DTP | 05/04/1949 | 10/30/1970 |
| Diphtheria & tetanus toxoids and pertussis vaccine adsorbed | 05/04/1949 | 10/30/1970 |
| Diphtheria toxoid | 02/01/1928 | 10/30/1970 |
| DT, adsorbed | 05/04/1949 | 10/30/1970 |
| DP, adsorbed | 05/04/1949 | 10/30/1970 |
| Pertussis vaccine | 08/03/1914 | 10/30/1970 |
| Pertussis vaccine, adsorbed | 05/03/1948 | 10/30/1970 |
| Plague | 05/14/1942 | |
| Poliomyelitis, inactivated monkey kidney cell | 04/12/1955 | 12/28/1978 |
| Small pox | 08/21/1903 | 06/11/1973 |
| Tetanus toxoid | 09/25/1940 | 11/01/1979 |
| Tetanus toxoid, adsorbed | 05/04/1949 | 10/30/1970 |
| Tetanus & diphtheria toxoids adsorbed (for adult use) | 11/16/1956 | 10/30/1970 |
| Typhoid | 03/06/1916 | 10/30/1970 |
| Organon Teknika Corporatione | ||
| BCG vaccine | 06/21/1989 | |
| Parke Davis, Division of Warner Lambert Companya | ||
| Adenovirus | 09/23/1957 | 07/29/1980 |
| Adenovirus and influenza, combined aluminium phosphate adsorbed | 09/22/1959 | 07/29/1980 |
| Diphtheria and tetanus toxoids | 07/29/1952 | 10/14/1981 |
| DTP | 07/29/1952 | 10/14/1981 |
| Diphtheria & tetanus toxoids & pertussis vaccine adsorbed | 07/08/1952 | 10/14/1981 |
| Diphtheria toxoid | 08/17/1927 | 10/14/1981 |
| DT, adsorbed | 07/08/1952 | 10/14/1981 |
| DTP adsorbed, poliomyelitis | 12/20/1963 | 10/14/1981 |
| DTP, poliomyelitis adsorbed | 03/25/1959 | 10/14/1981 |
| Influenza | 11/26/1945 | |
| Pertussis | 04/16/1952 | 10/14/1981 |
| Pertussis vaccine, adsorbed | 02/20/1952 | 10/14/1981 |
| Poliomyelitis, adsorbed | 10/04/1960 | 07/29/1980 |
| Poliomyelitis, inactivated monkey kidney cell | 04/12/1955 | 07/29/1980 |
| Rabies vaccine | 08/05/1942 | 03/21/1973 |
| Tetanus toxoid | 05/04/1940 | 10/14/1981 |
| Tetanus toxoid, adsorbed | 07/08/1952 | 10/14/1981 |
| Typhoid | 03/24/1916 | 02/24/1959 |
| Typhus | 03/25/1942 | 08/05/1947 |
| Pasteur Merieux Vaccins et Serums, S.A.b | ||
| Poliomyelitis, inactivated monkey kidney cell | 12/21/1990 | |
| Rabies vaccine | 06/09/1980 | |
| Pfizer Ltd.a | ||
| Poliovirus, live, oral trivalent | 10/28/1966 | 06/17/1979 |
| Poliovirus, oral type 1 | 08/17/1961 | 06/12/1979 |
| Poliovirus, oral type 2 | 10/06/1961 | 06/12/1979 |
| Poliovirus, oral type 3 | 03/27/1962 | 06/12/1979 |
| Praxis Biologics, Incorporatedd | ||
| Haemophilus b conjugate vaccine (diphtheria CRM197 protein conjugate) | 12/21/1988 | |
| Haemophilus b polysaccharide vaccine | 04/12/1985 | |
| Research Foundation for Microbial Diseases, Osaka University | ||
| Acellular pertussis vaccine concentrate | 08/20/1992 | |
| Japanese encephalitis virus vaccine inactivated | 12/10/1992 | |
| SCLAVO s.p.a.f | ||
| Cholera | 08/19/1976 | |
| Diphtheria and tetanus toxoids and pertussis vaccine adsorbed | 03/31/1978 | |
| Diphtheria toxoid | 01/04/1963 | |
| DT, adsorbed | 03/31/1978 | |
| Tetanus toxoid | 01/04/1963 | |
| Tetanus toxoid, adsorbed | 08/05/1970 | |
| Tetanus & diphtheria toxoids adsorbed (for adult use) | 02/16/1979 | |
| SmithKline Beechame | ||
| Hepatitis B, recombinant | 08/28/1989 | |
| Rubella virus, live | 03/12/1970 | 10/05/1982 |
| Swiss Serum Institute | ||
| Tetanus toxoid, adsorbed | 12/11/1970 | |
| Typhoid vaccine, oral, Ty21a | 12/15/1989 | |
| Takeda Chemical Industries, Ltd., | ||
| Acellular pertussis vaccine concentrate (for further manufacturing) | 12/17/1991 | |
| Texas Department of Health Resources | ||
| Diphtheria & tetanus toxoids & pertussis vaccine adsorbed | 07/27/1970 | 02/06/1979 |
| Diphtheria toxoid | 01/06/1963 | 02/06/1979 |
| DT, adsorbed | 07/27/1970 | 02/06/1979 |
| Pertussis | 12/27/1954 | 02/06/1979 |
| Tetanus toxoid | 09/22/1959 | 02/06/1979 |
| Tetanus & diphtheria toxoids adsorbed (for adult use) | 07/27/1970 | 02/06/1979 |
| Typhoid | 07/11/1950 | 02/06/1979 |
| University of Illinoisa | ||
| BCG vaccine | 07/07/1950 | 05/29/1987 |
| Wellcomed | ||
| Rubella virus, live | 03/01/1977 | |
| Wyeth Laboratories | ||
| Adenovirus, live, oral, type 4 | 07/01/1980 | |
| Adenovirus, live, oral, type 7 | 07/01/1980 | |
| Cholera | 07/16/1952 | |
| Diphtheria & tetanus toxoids and pertussis vaccine adsorbed | 09/11/1970 | |
| Diphtheria toxoid | 05/19/1944 | 05/19/1987 |
| DT, adsorbed | 09/11/1970 | |
| Influenza | 12/13/1961 | |
| Pertussis vaccine | 07/16/1952 | 05/19/1987 |
| Rabies vaccine | 08/11/1982 | 08/07/1986 |
| Smallpox | 05/19/1944 | |
| Tetanus toxoid | 05/19/1944 | |
| Tetanus toxoid, adsorbed | 09/11/1970 | |
| Tetanus & diphtheria toxoids adsorbed (for adult use) | 09/11/1970 | |
| Typhoid | 07/16/1952 | |
- a
Company no longer produces any vaccines.
- b
Connaught Laboratories, Inc., (U.S.) and Connaught Laboratories, Ltd (Canada), are subsidiaries of Pasteur-Mérieux Sérums et Vaccins (France).
- c
Evans-Medical is a division of Medeva International, plc (United Kingdom); Medeva International plc acquired the vaccine business from Wellcome in 1991.
- d
Lederle Laboratories acquired Praxis Biologics in 1989. Lederle-Praxis Biologicals is now a business unit of American Cyanamid.
- e
Company produces one vaccine only for U.S. market.
- f
Sclavo spa is now owned by Ciba-Geigy (Switzerland) and Chiron (U.S.).
SOURCE: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland.
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