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Have U.S. military personnel experienced health problems from being exposed to Agent Orange, its dioxin contaminants, and other herbicides used in Vietnam? This definitive volume summarizes the strength of the evidence associating exposure during Vietnam service with cancer and other health effects and presents conclusions from an expert panel.
Veterans and Agent Orange provides a historical review of the issue, examines studies of populations, in addition to Vietnam veterans, environmentally and occupationally exposed to herbicides and dioxin, and discusses problems in study methodology. The core of the book presents
- What is known about the toxicology of the herbicides used in greatest quantities in Vietnam.
- What is known about assessing exposure to herbicides and dioxin.
- What can be determined from the wide range of epidemiological studies conducted by different authorities.
- What is known about the relationship between exposure to herbicides and dioxin, and cancer, reproductive effects, neurobehavioral disorders, and other health effects.
This volume will be critically important to both policymakers and physicians in the federal government, Vietnam veterans and their families, veterans organizations, researchers, and health professionals.
Contents
- Committee To Review The Health Effects In Vietnam Veterans Of Exposure To Herbicides
- Foreword
- Preface
- 1. Executive Summary
- 2. History of the Controversy Over the Use of Herbicides
- MILITARY USE OF HERBICIDES IN VIETNAM
- EARLY CONCERNS ABOUT THE USE OF HERBICIDES IN VIETNAM
- CONCERNS ABOUT EXPOSURE TO AGENT ORANGE
- AGENT ORANGE PRODUCT LIABILITY LITIGATION
- CONCERNS ABOUT OTHER EXPOSURES TO 2,4,5-T AND TCDD
- THE FEDERAL GOVERNMENT'S RESPONSE TO PUBLIC CONCERNS
- RESPONSE BY OTHERS TO PUBLIC CONCERNS
- REFERENCES
- 3. The U.S. Military and the Herbicide Program in Vietnam
- 4. Toxicology
- 5. Methodologic Considerations in Evaluating the Evidence
- 6. Exposure Assessment
- 7. Epidemiologic Studies
- 8. Cancer
- CANCER EPIDEMIOLOGY
- SPECIFIC ISSUES WITH REGARD TO HERBICIDE EXPOSURE IN VIETNAM
- EXPOSURE
- PLAUSIBILITY DATA
- EXPECTED NUMBER OF CANCER CASES AMONG VIETNAM VETERANS
- OVERALL CANCER
- GASTROINTESTINAL TRACT TUMORS
- HEPATOBILIARY CANCERS
- NASAL/NASOPHARYNGEAL CANCER
- RESPIRATORY CANCERS
- BONE CANCER
- SOFT TISSUE SARCOMAS
- SKIN CANCERS
- CANCERS OF THE FEMALE REPRODUCTIVE SYSTEM AND BREAST
- GENITOURINARY CANCERS
- BRAIN TUMORS
- MALIGNANT LYMPHOMAS
- LEUKEMIA
- SUMMARY
- NOTE
- REFERENCES
- 9. Reproductive Effects
- 10. Neurobehavioral Disorders
- 11. Other Health Effects
- 12. Research Recommendations
- APPENDIXES
- Glossary
- Acronyms and Abbreviations
Support for this study was provided by the Department of Veterans Affairs (contract no. V101(93)P-1331).
NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.
This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.
The Institute of Medicine was chartered in 1970 by the National Academy of Sciences to enlist distinguished members of the appropriate professions in the examination of policy matters pertaining to the health of the public. In this, the Institute acts under the Academy's 1863 congressional charter responsibility to be an adviser to the federal government and its own initiative in identifying issues of medical care, research, and education. Dr. Kenneth I. Shine is president of the Institute of Medicine.
- NLM CatalogRelated NLM Catalog Entries
- Review Blue Water Navy Vietnam Veterans and Agent Orange Exposure[ 2011]Review Blue Water Navy Vietnam Veterans and Agent Orange ExposureInstitute of Medicine (US) Committee on Blue Water Navy Vietnam Veterans and Agent Orange Exposure. 2011
- Review Veterans and Agent Orange: Herbicide/Dioxin Exposure and Type 2 Diabetes[ 2000]Review Veterans and Agent Orange: Herbicide/Dioxin Exposure and Type 2 DiabetesInstitute of Medicine (US) Committee to Review the Evidence Regarding the Link Between Exposure to Agent Orange and Diabetes. 2000
- Review Veterans and Agent Orange: Update 1998[ 1999]Review Veterans and Agent Orange: Update 1998Institute of Medicine (US) Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Second Biennial Update). 1999
- Review Veterans and Agent Orange: Update 2008[ 2009]Review Veterans and Agent Orange: Update 2008Institute of Medicine (US) Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Seventh Biennial Update). 2009
- Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange.[Environ Health. 2019]Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange.Kelsey KT, Rytel M, Dere E, Butler R, Eliot M, Huse SM, Houseman EA, Koestler DC, Boekelheide K. Environ Health. 2019 Oct 29; 18(1):91. Epub 2019 Oct 29.
- Veterans and Agent OrangeVeterans and Agent Orange
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