This new edition--a must for all researchers who use these lab animals-- provides practical suggestions for breeding, keeping, and identifying pathogen-free laboratory rodents. It contains three informative sections. The first, Principles of Rodent Disease Prevention, summarizes methods for eliminating infectious agents. It offers information on pathogen terminology; pathogen status of rodents; and breeding, transporting, isolating, testing, and diagnosing rodents. The second section, Individual Disease Agents and Their Effects on Research, describes the diagnosis and control of each infectious agent, and the last section, Diagnostic Indexes: Clinical Signs, Pathology, and Research Complications, contains informative tables covering all the diseases listed in the volume, arranged to help in the diagnosis of infected animals.

Contents

• COMMITTEE ON INFECTIOUS DISEASES OF MICE AND RATS
• INSTITUTE OF LABORATORY ANIMAL RESOURCES COUNCIL
• COMMISSION ON LIFE SCIENCES
• PREFACE
• PART I. PRINCIPLES OF RODENT DISEASE PREVENTION
  • 1. Objectives, Terminology, and Overview of Pathogen Status
    • Scientific Objectives
    • Infection Versus Disease
    • Terminology of Microbial and Pathogen Status
    • Pathogen Status of Contemporary Rodents
  • 2. Breeding, Transportation, and Use of Pathogen-free Rodents
  • 3. Barrier Programs
    • Barrier Facilities
    • Barrier Rooms
    • Isolators as Barriers
    • Airflow Systems as Barriers
    • Barrier Cages
  • 4. Health Surveillance Programs
    • Scientific Objectives
    • Agent Detection Objectives
    • Test Procedures
    • Sampling Strategies
    • Test Frequency
    • Sentinel Animals
    • Rodent Diagnostic Laboratories
• PART II. INDIVIDUAL DISEASE AGENTS AND THEIR EFFECTS ON RESEARCH
  • 5. Introduction
  • 6. Respiratory System
    • Overview
    • Sendai Virus
    • Mycoplasma pulmonis
    • Cilia-Associated Respiratory Bacillus
    • Streptococcus pneumoniae
    • Corynebacterium kutscheri
    • Rat Coronavirus
    • Pneumonia Virus of Mice
    • Mycobacterium avium-intracellulare
    • Pneumocystis carinii
    • Chlamydia trachomatis
    • Chlamydia psittaci
    • Klebsiella pneumoniae
    • Streptococcus pyogenes
    • Mycoplasma neurolyticum
    • Mycoplasma collis
    • K Virus
  • 7. Digestive System
    • Overview
    • Mouse Cytomegalovirus
    • Rat Cytomegalovirus
    • Mouse Thymic Virus
    • Sialodacryoadenitis Virus
    • Mouse Hepatitis Virus
    • Mouse Rotavirus
    • Rat Rotavirus-Like Agent
    • Reovirus-3
    • Adenoviruses
    • Bacillus piliformis
    • Salmonella enteritidis
    • Citrobacter freundii (Biotype 4280)
    • Pseudomonas aeruginosa
    • Common Endoparasites
    • Other Endoparasites
  • 8. Skin and Joints
    • Overview
    • Ectromelia virus
    • Poxvirus(es) in Rats
    • Mycoplasma arthritidis
    • Streptobacillus moniliformis
    • Common Ectoparasites
    • Noninfectious Skin Conditions Important In Differential Diagnosis
  • 9. Hemopoietic System
    • Overview
    • Lymphocytic Choriomeningitis Virus
    • Lactic Dehydrogenase-Elevating Virus
    • Haemobartonella muris
    • Eperythrozoon coccoides
    • Murine Leukemia Viruses
  • 10. Central Nervous System
    • Overview
    • Theiler's Virus
    • Encephalitozoon cuniculi
  • 11. Genitourinary System
    • Overview
    • Leptospira interrogans serovar ballum
    • Mycoplasma muris
  • 12. Multiple Systems
    • Overview
    • Kilham Rat Virus
    • H-1 Virus
    • Minute Virus of Mice
    • Polyoma Virus
    • Hantaviruses
• PART III. INDEXES TO DIAGNOSIS AND RESEARCH COMPLICATIONS OF INFECTIOUS AGENTS
  • Introduction
  • Clinical Signs
    • A
    • B
    • C
    • D
    • E
    • F
    • G
    • H
    • I
    • J
    • K
    • L
    • M
    • O
    • P
    • R
    • S
    • T
    • W
  • Pathology
    • A
    • B
    • C
    • D
    • E
    • F
    • G
    • H
    • I
    • K
    • L
    • M
    • N
    • O
    • P
    • R
    • S
    • T
    • U
  • Research Complications
    • A
    • C
    • I
    • Z
• REFERENCES

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences. National Academy of Engineering, and Institute of Medicine.

The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Frank Press is president of the National Academy of Sciences.

The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Robert M. White is president of the National Academy of Engineering.

The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and upon its own initiative to identify issues of medical care, research, and education. Dr. Samuel O. Thier is president of the Institute of Medicine.

The National Research Council was established by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy's purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and National Academy of Engineering in the conduct of their services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Frank Press and Dr. Robert M. White are chairman and vice-chairman, respectively, of the National Research Council.