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National Research Council (US) Committee on Applications of Toxicogenomics to Cross-Species Extrapolation. Application of Toxicogenomics to Cross-Species Extrapolation: A Report of a Workshop. Washington (DC): National Academies Press (US); 2005.

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Application of Toxicogenomics to Cross-Species Extrapolation: A Report of a Workshop.

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Toxicogenomics has been described as a discipline combining expertise in toxicology, genetics, molecular biology, and environmental health to elucidate the response of living organisms to stressful environments. It includes, but is not limited to, the study of how genomes respond to toxicant exposures and how genotype affects responses to toxicant exposures. As the technology rapidly develops, it is critical that scientists and the public communicate about the promises and limitations of this new field. Despite the dependence on animal models in toxicologic research for predicting human health effects in the regulatory arena, there can be important differences between how animals and humans respond to different chemicals. The Committee on Applications of Toxicogenomics to Cross-Species Extrapolation designed a workshop to consider using toxicogenomics in cross-species extrapolation from animals to humans. The workshop reflected on the promises and limitations of emerging data-rich approaches—such as genotyping (genomics), mRNA analysis (transcriptomics), protein analysis (proteomics), and metabolite analysis (metabolomics)—to inform cross-species extrapolation. Specifically, the workshop considered whether the data-rich technologies offer new ways of determining whether the effects of chemicals in test animals can be used to predict human responses.

This workshop report has been reviewed in draft form by persons chosen for their diverse perspectives and technical expertise in accordance with procedures approved by the National Research Council’s Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published workshop report as sound as possible and to ensure that the report meets institutional standards of objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following people for their review of this workshop report: Susan Sumner, RTI International; Jonathan H. Freedman, Duke University; Kevin W. Gaido, CIIT Centers for Integrated Genomics; and Frank A. Witzmann, Indiana University School of Medicine.

Although the reviewers listed above have provided many constructive comments and suggestions, they were not asked to endorse the conclusions or recommendations, nor did they see the final draft of the workshop report before its release. The review of the workshop report was overseen by Rogene Henderson, of the Lovelace Respiratory Research Institute. Appointed by the National Research Council, she was responsible for making certain that an independent examination of the workshop report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of the workshop report rests entirely with the committee and the institution.

The committee gratefully acknowledges the following for making presentations at the workshop: John L. Butenhoff, 3M Company; Frank A. Witzmann, Indiana University School of Medicine; William H. Benson, Stephen Nesnow, and Kerry L. Dearfield, U.S. Environmental Protection Agency; Richard T. Di Giulio, Duke University; Donna Mendrick, Gene Logic Inc.; Susan Sumner, RTI International; and Russell Thomas, CIIT Centers for Health Research.

The committee is grateful for the assistance of the National Research Council staff in preparing this workshop summary: Marilee Shelton-Davenport, Roberta Wedge, and Karl Gustavson, project directors; James Reisa, director of the Board on Environmental Studies and Toxicology; Fran Sharples, director of the Board on Life Sciences; Jennifer Saunders and Mirsada Karalic-Loncarevic, research associates; Jennifer Roberts, postdoctoral research associate; Norman Grossblatt, senior editor; Lucy Fusco and Jordan Crago, senior program assistants; and Sammy Bardley, librarian.

Finally, I thank the members of the committee for their dedicated efforts throughout the development of this workshop summary.

N. Leigh Anderson

Chair, Committee on Application of Toxicogenomics to Cross-Species Extrapolation

Copyright © 2006, National Academy of Sciences.
Bookshelf ID: NBK22822


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