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Cover of Application of Toxicogenomics to Cross-Species Extrapolation

Application of Toxicogenomics to Cross-Species Extrapolation

A Report of a Workshop

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Washington (DC): National Academies Press (US); .
ISBN-10: 0-309-10084-4

Toxicogenomics has been described as a discipline combining expertise in toxicology, genetics, molecular biology, and environmental health to elucidate the response of living organisms to stressful environments. It includes, but is not limited to, the study of how genomes respond to toxicant exposures and how genotype affects responses to toxicant exposures. As the technology rapidly develops, it is critical that scientists and the public communicate about the promises and limitations of this new field. Despite the dependence on animal models in toxicologic research for predicting human health effects in the regulatory arena, there can be important differences between how animals and humans respond to different chemicals. The Committee on Applications of Toxicogenomics to Cross-Species Extrapolation designed a workshop to consider using toxicogenomics in cross-species extrapolation from animals to humans. The workshop reflected on the promises and limitations of emerging data-rich approaches—such as genotyping (genomics), mRNA analysis (transcriptomics), protein analysis (proteomics), and metabolite analysis (metabolomics)—to inform cross-species extrapolation. Specifically, the workshop considered whether the data-rich technologies offer new ways of determining whether the effects of chemicals in test animals can be used to predict human responses.

Contents

This project was supported by Contract No. N01-OD-4-2139 between the National Academy of Sciences and National Institute of Environmental Health Sciences. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project.

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

Copyright © 2006, National Academy of Sciences.
Bookshelf ID: NBK22820PMID: 20669461DOI: 10.17226/11488

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