Table 29.4Antibiotic inhibitors of protein synthesis

AntibioticAction
Streptomycin and other aminoglycosidesInhibit initiation and cause misreading of mRNA (prokaryotes)
TetracyclineBinds to the 30S subunit and inhibits binding of aminoacyl-tRNAs (prokaryotes)
ChloramphenicolInhibits the peptidyl transferase activity of the 50S ribosomal subunit (prokaryotes)
CycloheximideInhibits the peptidyl transferase activity of the 60S ribosomal subunit (eukaryotes)
ErythromycinBinds to the 50S subunit and inhibits translocation (prokaryotes)
PuromycinCauses premature chain termination by acting as an analog of aminoacyl-tRNA (prokaryotes and eukaryotes)

From: Section 29.5, Eukaryotic Protein Synthesis Differs from Prokaryotic Protein Synthesis Primarily in Translation Initiation

Cover of Biochemistry
Biochemistry. 5th edition.
Berg JM, Tymoczko JL, Stryer L.
New York: W H Freeman; 2002.
Copyright © 2002, W. H. Freeman and Company.

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