Figure 15.16. Protein Kinase C Activation.
Figure 15.16. Protein Kinase C Activation.

Figure 15.16Protein Kinase C Activation

Figure 15.16. Protein Kinase C Activation. (A) The C1 domain of PKC, structurally organized around two bound zinc ions, binds diacylglycerol. (B) When the C1 domains bind to diacylglycerol in the membrane, the pseudosubstrate is pulled from the active site, permitting catalysis. Calcium-binding C2 domains help to localize PKC to the membrane.

From: Section 15.2, The Hydrolysis of Phosphatidyl Inositol Bisphosphate by Phospholipase C Generates Two Messengers

Cover of Biochemistry
Biochemistry. 5th edition.
Berg JM, Tymoczko JL, Stryer L.
New York: W H Freeman; 2002.
Copyright © 2002, W. H. Freeman and Company.

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