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Institute of Medicine (US) Committee on Cancer Clinical Trials and the NCI Cooperative Group Program; Nass SJ, Moses HL, Mendelsohn J, editors. A National Cancer Clinical Trials System for the 21st Century: Reinvigorating the NCI Cooperative Group Program. Washington (DC): National Academies Press (US); 2010.

Cover of A National Cancer Clinical Trials System for the 21st Century

A National Cancer Clinical Trials System for the 21st Century: Reinvigorating the NCI Cooperative Group Program.

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Acronyms

AACI

Association of American Cancer Institutes

AAMC

American Association of Medical Colleges

ACOSOG

American College of Surgeons Oncology Group

ACRIN

American College of Radiology Imaging Network

ACS CAN

American Cancer Society Cancer Action Network

AE

adverse event

AHRQ

Agency for Healthcare Research and Quality

AIPC

androgen-independent prostate cancer

ALERT

Act 21st Century Cancer Access to Life-Saving Early Detection, Research, and Treatment Act

ALL

acute lymphoblastic leukemia

AML

acute myeloid leukemia

ARRA

American Recovery and Reinvestment Act of 2009

ASCO

American Society of Clinical Oncology

BCG

bacillus Calmette-Guérin

BICR

blinded independent central review

BIG

Breast International Group

BRB

Biometric Research Branch

BSA

Board of Scientific Advisors (National Cancer Institute)

CALGB

Cancer and Leukemia Group B

CCG

Children’s Cancer Group

CCOP

Community Clinical Oncology Program

CCSG

Cancer Center Support Grant

CER

comparative effectiveness research

CHOP

cyclophosphamide, doxorubicin, vincristine, and prednisone

CIRB

central institutional review board

CLL

chronic lymphocytic leukemia

CMS

Centers for Medicare & Medicaid Services

COG

Children’s Oncology Group

CRADA

Cooperative Research and Development Agreement

CRI

Clinical Research Initiative (Association of American Cancer Institutes)

CSDD

Center for the Study of Drug Development

CT

computed tomography

CTAC

Clinical Trials Advisory Committee

CTEP

Cancer Therapy Evaluation Program

CTMB

Clinical Trials Monitoring Branch

CTROC

Clinical Trials and Translational Research Operations Committee

CTSA

Clinical and Translational Science Awards

CTSU

Cancer Trials Support Unit

CTTI

Clinical Trials Transformation Initiative

CTU

Clinical Trials Unit

CTWG

Clinical Trials Working Group

CYP2D6

cytochrome P-450 2D6

DCE-MRI

dynamic contrast-enhanced magnetic resonance imaging

DCPC

Division of Cancer Prevention and Control

DCTD

Division of Cancer Treatment and Diagnosis

DCTDC

Division of Cancer Treatment, Diagnosis, and Centers

ECOG

Eastern Cooperative Oncology Group

EGFR

epidermal growth factor receptor

EMR

electronic medical record

EORTC

European Organisation for Research and Treatment of Cancer

ER

estrogen receptor

ERISA

Employee Retirement Income Security Act of 1974

5-FU

fluorouracil

18F-FDG

fluorine-18 fluorodeoxyglucose

FDA

Food and Drug Administration

FDAAA

Food and Drug Administration Amendments Act of 2007

FNIH

Foundation for the National Institutes of Health

FOLFOX4

oxaliplatin, 5-fluorouracil, and leucovorin

FTE

full-time equivalent

GIST

gastrointestinal stromal tumors

GOG

Gynecologic Oncology Group

HER-2

human epidermal growth factor receptor 2

HHS

U.S. Department of Health and Human Services

HIPAA

Health Insurance Portability and Accountability Act

ICF

informed-consent form

IDB

Investigational Drug Branch

IDE

investigational device exemption

IND

investigational new drug

IOM

Institute of Medicine

IP

intellectual property

IRB

institutional review board

I-SPY TRIAL

Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular analysis

KRAS

Kirsten ras

LOI

letter of intent

MAMS

multiarm, multistage (trial design)

MARVEL

Marker Validation for Erlotinib in Lung cancer

MINDACT

Microarray in Node-negative Disease may Avoid ChemoTherapy

MMRC

Multiple Myeloma Research Consortium

MRC

Medical Research Council

MRD

minimal residual disease

MRI

magnetic resonance imaging

NBL

neuroblastoma

NCAB

National Cancer Advisory Board

NCCF

National Children’s Cancer Foundation

NCCN

National Comprehensive Cancer Network

NCCTG

North Central Cancer Treatment Group

NCD

National Coverage Decision

NCI

National Cancer Institute

NIH

National Institutes of Health

NNCO

National Nanotechnology Coordination Office

NSABP

National Surgical Adjuvant Breast and Bowel Project

NSCLC

non-small-cell lung cancer

NSET

Nanoscale Science, Engineering, and Technology Subcommittee

OCR

Office for Civil Rights (U.S. Department of Health and Human Services)

OEWG

Operational Efficiency Working Group

OHRP

Office for Human Research Protections (U.S. Department of Health and Human Services)

pCR

pathologic complete response

PERCIST

PET Response Criteria in Solid Tumors

PET

positron emission tomography

Ph+

Philadelphia chromosome positive

POG

Pediatric Oncology Group

QIBA

Quantitative Imaging Biomarkers Alliance

QOPI

Quality Oncology Practice Initiative

RECIST

Response Evaluation Criteria in Solid Tumors

RTOG

Radiation Therapy Oncology Group

SACHRP

Secretary’s Advisory Committee on Human Research Protections

SPECT

single-photon emission computed tomography

SPORE

Specialized Programs of Research Excellence

STAMPEDE

Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy

STPI

Science and Technology Policy Institute

SWOG

Southwest Oncology Group

TAILORx

Trial Assigning IndividuaLized Options for Treatment

TRWG

Translational Research Working Group

Tufts CSDD

Tufts Center for the Study of Drug Development

US

ultrasound

VA

U.S. Department of Veterans Affairs

VEGF

vascular endothelial growth factor

Copyright 2010 by the National Academy of Sciences. All rights reserved.
Bookshelf ID: NBK220380

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