Figure 21-4. The mitochondrial respiratory chain.

Figure 21-4

The mitochondrial respiratory chain. Nuclear DNA-encoded subunits are in red, mtDNA-encoded subunits are in purple. Protons (H+) are pumped from the matrix to the intermembranous space through complexes I, III, and IV. They flow back into the matrix through complex V (ATP synthetase) with the concomitant production of ATP. Coenzyme Q10 (CoQ) and cytochrome c (Cyt c) are nucleus-encoded electron-transfer proteins. ND, NADH dehydrogenase; SDH, succinate dehydrogenase; COX, cytochrome oxidase; A6 and A8, subunits of the ATP synthetase complex V. (After S. DiMauro et al., “Mitochondria in Neuromuscular Disorders,” Biochimica et Biophysica Acta 1366, 1998, 199–210.)

From: Structure of organelle chromosomes

Cover of An Introduction to Genetic Analysis
An Introduction to Genetic Analysis. 7th edition.
Griffiths AJF, Miller JH, Suzuki DT, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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