AEGL-2 VALUES

10 min30 min1 h4 h8 h
0.75 ppm0.75 ppm0.75 ppm0.75 ppm0.75 ppm
Weight-of -evidence approach suggests 0.75 ppm induced moderate bronchoconstriction in exercising asthmatics.
0.75 ppm0.75 ppm0.75 ppm0.75 ppm0.75 ppm
Time Scaling: The role of exposure duration to the magnitude of SO2-induced bronchoconstriction in asthmatics appears to decrease with extended exposure. Data suggest that a major portion of the SO2-induced bronchoconstriction occurs within 10-min and increases minimally or resolves beyond 10-min of exposure. Therefore, AEGL-2 values for SO2 were held constant across all time points.
Data adequacy: Robust data base of controlled studies in both healthy and asthmatic humans.

From: 9, Sulfur Dioxide Acute Exposure Guideline Levels

Cover of Acute Exposure Guideline Levels for Selected Airborne Chemicals
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 8.
National Research Council (US) Committee on Acute Exposure Guideline Levels.
Washington (DC): National Academies Press (US); 2010.
Copyright 2010 by the National Academy of Sciences. All rights reserved.

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