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Lodish H, Berk A, Zipursky SL, et al. Molecular Cell Biology. 4th edition. New York: W. H. Freeman; 2000.

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Molecular Cell Biology. 4th edition.

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Figure 11-51. Splicing mechanisms in group I and group II self-splicing introns and spliceosome-catalyzed splicing of pre-mRNA.

Figure 11-51Splicing mechanisms in group I and group II self-splicing introns and spliceosome-catalyzed splicing of pre-mRNA

The intron is shown in blue; the exons to be joined in red. In group I introns, a guanosine cofactor (G) that is not part of the RNA chain associates with the active site. The 3′-hydroxyl group of this guanosine participates in a transesterification reaction with the phosphate at the 5′ end of the intron; this reaction is analogous to that involving the 2′-hydroxyl groups of the branch-site A in group II introns and pre-mRNA introns spliced in spliceosomes (see Figure 11-16). The subsequent transesterification that links the 5′ and 3′ exons is similar in all three splicing mechanisms. Note that spliced-out group I introns are linear structures, unlike the branched intron products in the other two cases. [Adapted from P. A. Sharp, 1987, Science 235:769.]

Image ch11f16

From: Section 11.6, Processing of rRNA and tRNA

Copyright © 2000, W. H. Freeman and Company.

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