Figure 22-19. Structure of laminin, a large heterotrimeric multiadhesive matrix protein found in all basal laminae.

Figure 22-19Structure of laminin, a large heterotrimeric multiadhesive matrix protein found in all basal laminae

The cross-shaped molecule contains globular domains and a coiled-coil region in which the three chains are covalently linked via several disulfide bonds. Different regions of laminin bind to cell-surface receptors and various matrix components. [Adapted from G. R. Martin and R. Timpl, 1987, Ann. Rev. Cell Biol. 3:57; and K. Yamada, 1991, J. Biol. Chem. 266:12809.]

From: Section 22.4, Noncollagen Components of the Extracellular Matrix

Cover of Molecular Cell Biology
Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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