Figure 24-11. Children with hereditary retinoblastoma develop retinal tumors early in life and generally in both eyes.

Figure 24-11Children with hereditary retinoblastoma develop retinal tumors early in life and generally in both eyes

They inherit one mutant allele of the RB gene. Somatic mutation of the other allele coupled with oncogenic mutations in other genes leads to tumor development. [Courtesy of T. Dryja.]

From: Section 24.2, Proto-Oncogenes and Tumor-Suppressor Genes

Cover of Molecular Cell Biology
Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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