Figure 17-2. Uptake-targeting sequences of imported mitochondrial proteins.

Figure 17-2Uptake-targeting sequences of imported mitochondrial proteins

All such proteins have an N-terminal matrix-targeting sequence (red) that is similar but not identical in different proteins. Proteins destined for the intermembrane space and outer membrane have an additional targeting sequence that functions to direct proteins to these locations by several different mechanisms described later. Except in the case of outer-membrane proteins, the targeting sequences are removed from the remainder of the polypeptide chain (blue wavy line), leaving the mature protein sequence. [After E. C. Hurt and A. P. G. M. van Loon, 1986, Trends Biochem. Sci. 11:204, and F. U. Hartl et al., 1989, Biochem. Biophys. Acta 988:1.]

From: Section 17.1, Synthesis and Targeting of Mitochondrial and Chloroplast Proteins

Cover of Molecular Cell Biology
Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.