Figure 22-4. Interactions between cell-adhesion molecules during the initial binding and tight binding of T cells, a kind of leukocyte, to activation endothelial cells.

Figure 22-4Interactions between cell-adhesion molecules during the initial binding and tight binding of T cells, a kind of leukocyte, to activation endothelial cells

Once a T cell has firmly adhered to the endothelium, it can move (extravasate) into the underlying tissue. Activation of the endothelium requires signals, such as platelet-activating factor (PAF), that are released in areas of infection or inflammation; thus extravasation occurs only in such areas. See text for discussion. [Adapted from R. O. Hynes and A. Lander, 1992, Cell 68:303.]

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From: Section 22.1, Cell-Cell Adhesion and Communication

Cover of Molecular Cell Biology
Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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