Table 22-3Major Collagen Molecules

TypeMolecule CompositionStructural FeaturesRepresentative Tissues
Fibrillar Collagens
I[α1(I)]2[α2(I)]300-nm-long fibrilsSkin, tendon, bone, ligaments, dentin, interstitial tissues
II[α1(II)]3300-nm-long fibrilsCartilage, vitreous humor
III[α1(III)]3300-nm-long fibrils; often with type ISkin, muscle, blood vessels
V[α1(V)]3390-nm-long fibrils with globular N-terminal domain; often with type ISimilar to type I; also cell cultures, fetal tissues
Fibril-Associated Collagens
VI[α1(VI)][α2(VI)]Lateral association with type I; periodic globular domainsMost interstitial tissues
IX[α1(IX)][α2(IX)][α3(IX)]Lateral association with type II; N-terminal globular domain; bound glycosaminoglycanCartilage, vitreous humor;
Sheet-Forming Collagens
IV[α1(IV)]2[α2(IV)]Two-dimensional networkAll basal laminaes

SOURCE: K. Kuhn, 1987, in R. Mayne and R. Burgeson, eds., Structure and Function of Collagen Types, Academic Press, p. 2; M. van der Rest and R. Garrone, 1991, FASEB J. 5:2814.

From: Section 22.3, Collagen: The Fibrous Proteins of the Matrix

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Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
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