Figure 10-39. Schematic diagrams illustrating the modular structure of eukaryotic transcription activators.

Figure 10-39Schematic diagrams illustrating the modular structure of eukaryotic transcription activators

These transcription factors may contain more than one activation domain but rarely contain more than one DNA-binding domain. Gal4 and Gcn4 are yeast transcription activators. The glucocorticoid receptor (GR), which also contains a hormone-binding domain (not shown), activates transcription of target genes in the presence of certain hormones. SP1 binds to GC-rich promoter elements in a large number of mammalian genes. The relatively unstructured, highly flexible protein domains in activators are extremely sensitive to digestion by proteases.

From: Section 10.5, Eukaryotic Transcription Activators and Repressors

Cover of Molecular Cell Biology
Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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