Figure 18-38. Experimental demonstration that myosin II is required for cytokinesis.

Figure 18-38Experimental demonstration that myosin II is required for cytokinesis

The activity of myosin II was inhibited either by deleting its gene or by microinjecting anti-myosin II antibodies into a cell. A cell that lacked myosin II was able to replicate its DNA and nucleus, but it failed to divide; this defect caused the cell to become large and multinucleate. In comparison, an untreated cell during the same period continued to divide and formed a multicellular ball of cells in which each cell contained a single nucleus.

From: Section 18.5, Actin and Myosin in Nonmuscle Cells

Cover of Molecular Cell Biology
Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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