Figure 8-3. The use of colchicine to generate a diploid from a monoploid.

Figure 8-3

The use of colchicine to generate a diploid from a monoploid. Colchicine added to mitotic cells during metaphase and anaphase disrupts spindle fiber formation, preventing the migration of chromatids after the centromere is split. A single cell is created that contains pairs of identical chromosomes that are homozygous at all loci.

From: Changes in Chromosome Number

Cover of Modern Genetic Analysis
Modern Genetic Analysis.
Griffiths AJF, Gelbart WM, Miller JH, et al.
New York: W. H. Freeman; 1999.
Copyright © 1999, W. H. Freeman and Company.

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