Key Characteristics of GenBank versus RefSeq

GenBankRefSeq
Not curatedCurated
Author submits NCBI creates from existing data
Only author can revise NCBI revises as new data emerge
Multiple records for same loci commonSingle records for each molecule of major organisms
Records can contradict each other
No limit to species includedLimited to model organisms
Data exchanged among INSDC membersExclusive NCBI database
Akin to primary literatureAkin to review articles
Proteins identified and linked  Proteins and transcripts identified and linked
Access via NCBI Nucleotide databases Access via Nucleotide & Protein databases

From: Chapter 1, GenBank: The Nucleotide Sequence Database

Cover of The NCBI Handbook
The NCBI Handbook [Internet].
McEntyre J, Ostell J, editors.
Bethesda (MD): National Center for Biotechnology Information (US); 2002-.

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