Box 1Annotation of other genomes

NCBI may assemble a genome prior to annotation, add annotations to a genome assembled elsewhere, or simply process an annotated genome to produce RefSeqs and maps for display in Map Viewer (Chapter 20).

The basic procedures used to annotate other eukaryotic genomes are essentially the same as those used to annotate the human genome. However, the overall process is adjusted to accommodate the different types of input data that are available for each organism. Genes can be annotated on any genome for which a significant number of mRNA, EST, or protein sequences are available. Other features, such as clones, STS markers, and SNPs, can also be annotated whenever the relevant data are available for an organism.

For example, genes and other features are placed on the mouse Whole Genome Shotgun (WGS) assembly from the Mouse Genome Sequencing Consortium (MGSC) by skipping the assembly steps used in the human process but following the annotation steps with relatively minor adjustments. A variation of the human process is also used to assemble and annotate genomic contigs from finished mouse clone sequences (see the Map Viewer display of the mouse genome).

From: Chapter 14, Genome Assembly and Annotation Process

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The NCBI Handbook [Internet].
McEntyre J, Ostell J, editors.
Bethesda (MD): National Center for Biotechnology Information (US); 2002-.

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