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National Research Council (US) Committee on Acute Exposure Guideline Levels; National Research Council (US) Committee on Toxicology. Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels: Part A. Washington (DC): National Academies Press (US); 2011.

Cover of Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels: Part A

Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels: Part A.

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CHLOROSILANES

At its meeting held on October 26-29, 2010, the committee reviewed the TSD on 26 selected chlorosilanes. A presentation on the TSD was made by Julie Klotzbach, of Syracuse Research Corporation. The following is excerpted from the Executive Summary of the TSD:

Chlorosilanes contain one or more chlorine atoms covalently bonded to a silicon atom; the maximum Cl:Si ratio is four…. Data suggest that the acute toxicity of chlorosilanes is largely explained by the hydrogen chloride hydrolysis product…. Based on these data, and in the absence of appropriate chemical-specific data for the chlorosilanes considered in this document, the hydrogen chloride AEGLs were used to derive the chlorosilane AEGLs.

This document can be finalized when the committee comments are adequately addressed.

AEGL-Specific Comments

The committee approved the AEGL-1, AEGL-2, and AEGL-3 derivations for the 26 selected chlorosilanes.

Other Comments

A recommendation in the Eighteenth Interim Report of the Committee on Acute Exposure Guidelines (NRC 2010) regarding publishing the chlorosilanes TSD with the HCl document was not intended to delay publication; it was intended for consideration at such a time as the HCl document was reviewed, revised, and reissued.

The Data Adequacy and Research Needs section as revised can serve as an excellent example of the intent for this section, as defined in the SOP on pages 53-57.

Page 15, Lines 14-22: In support of the “HCl-is-the-toxic-moiety hypothesis,” the TSD discusses a 1-h LC50 study done with HCl. For clarity and completeness in referencing this study, the discussion should indicate that this was an unpublished study done in the same laboratory as that described in Jean et al. 2006 (see page 520, column 2 of the article).

Comment References

  • Jean, P.A., R.H. Gallavan, G.B. Kolesar, W.H. Siddiqui, J.A. Oxley, and R.G. Meeks. 2006. Chlorosilane acute inhalation toxicity and development of an LC50 prediction model. Inhal. Toxicol. 18(8):515-522. [PubMed: 16717023]
  • NRC (National Research Council). 2010. Eighteenth Interim Report of the Committee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press.
Copyright 2011 by the National Academy of Sciences. All rights reserved.
Bookshelf ID: NBK209464

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