Table 46.1Common Dosage Schedules Used for MTX

Daily continuous (5–10 mg/day)Not used anymore
Weekly, biweekly (15–25 mg in single or divided doses)Used mainly to treat psoriasis or rheumatoid arthritis
Weekly or biweekly (20–30 mg/m2)Used in maintenance treatment of ALL
Pulse weekly (30–60 mg/m2)Used for choriocarcinoma, ALL
Intermediate dose: 120–500 mg/m2 given weeklyRequires LV “rescue” 10–15 mg/m2 q6h × 6–8 doses
High-dose: 500 to 12,000 mg/m2 weekly or every other weekUsed in osteosarcoma, ALL. Requires LV “rescue”

From: Chapter 46, Folate Antagonists

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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