Table 26.4The effects of dietary fat intake (12, 24, 48% of calories) on 7, 12-dimethylbenz (a) anthracene (DMBA)-induced mammary carinogenesis in female rats61*

Dietary Fat (% kcal)Number of RatsDaily Energy Intake (Kcal/d) Final Body Weight (g)Adenocarinoma (%)Number of Cancers

Rats were fed diets with corn oil providing 12, 24, or 48% of total energy from 4 weeks of age for a period of 30 weeks. DMBA was given as a single dose (2.0 mg/100 g body weight) after 4 weeks of feeding. Each doubling of energy intake from fat multiplied the odds of developing an adenocarcinoma by 2.7 (p < 0.001).

From: Chapter 26, Nutrition in the Etiology and Prevention of Cancer

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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