Table 11.1General Features of Hereditary Cancer Syndromes

• Same or linked forms of cancer in two or more close relatives
• Earlier than usual cancer onset in one or more relatives
• Bilateral cancer in paired organs
• Multiple primary tumors in the same individual
• Specific constellation of tumors are part of known cancer syndrome
• Evidence of autosomal dominant transmission of cancer susceptibility

From: Chapter 11, Genetic Predisposition to Cancer

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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