Table 44.3Potential Sources of Interpatient Pharmacokinetic Variability in Cancer Patients

Abnormalities of absorption
Nausea/vomiting
Prior surgery, radiotherapy, or chemotherapy
Concurrent antiemetics affecting gut motility
Patient compliance
Concomitant medications
Abnormalities of distribution
Weight loss
Obesity
Decreased body fat (lipophilic drugs)
Pleural effusions or ascites (methotrexate)
Abnormalities of elimination
Hepatic dysfunction due to tumor replacement or prior (or concurrent) therapy
Renal dysfunction due to malignant involvement or prior (or concurrent) therapy
Concomitant medications
Abnormalities in protein binding
Hypoalbuminemia
Concomitant medications

From: Chapter 44, Pharmacology

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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