Table 44.1Activation of Anticancer Drugs

Activation ReactionDrug
AquationCisplatin
HydrolysisIrinotecan
PolyglutamylationMethotrexate
PhosphorylationCytarabine
Fludarabine
Cladribine
Phosphoribosylation5-Fluorouracil
6-Mercaptopurine
6-Thioguanine
Microsomal oxidationCyclophosphamide
Ifosfamide
Procarbazine
Microsomal reductionBleomycin
DemethylationDacarbazine
Hexamethylmelamine
AcetylationAmonafide

From: Chapter 44, Pharmacology

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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