Table 64.23Interleukin-17

Characteristic176Comment
Chromosomal localization32q31
Major sites of productionCD4+ activated memory T-cells (CD45+, Ro+)
Selected biologic activities• May mediate, in part, T-cell contribution to inflammationHomologous to open reading frame 13 of Herpesvirus saimiri172
• Stimulates epithelial, endothelial, fibroblastic and macrophage cells to express a variety of inflammatory cytokines
• Promotes the capacity of fibroblasts to sustain hematopoietic progenitor growth
• Promotes differentiation of dendritic cell progenitors
• May be involved in the pathogenesis of rheumatoid arthritis and graft rejection
ReceptorIL-17 receptor and epithelial cellsUbiquitously expressed on hematopoietic
Located at 22q111.22-23

IL-17 = interleukin-17.

From: Chapter 64, Hematopoietic Growth Factors

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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