| Phenotype | Cell lines (typical) | [6-4] repair* | Incision† | UDS‡ | Dimer repair§ | UV resistance|| |
|---|---|---|---|---|---|---|
| Normal | AG1218A | 100 | 100 | 100 | 100 | 100 |
| Normal | HeLa | 100 | 100 | 100 | 100 | 100 |
| XP-A | XP12RO | < 10 | < 10 | < 5 | < 5 | < 15 |
| XP-A rev# | XP129 | 80 | > 80 | 50-90 | < 5 | 100 |
| XP-C | XP1BE | < 25 | 30approx | < 15 | < 10 | 40 |
| XP-D | XP6BE | < 10 | 15-40 | 25 | < 20 | 10 |
| XP-E | XP2RO | 75approx | 40-60 | 40approx | 70 | |
| XP-V | XP4BE | 100 | >100 | 70 | > 90 | 65 |
| XP-D/TTD | TTD1GL | 100 | 100 | 100 | 100 | 100 |
| XP-D/TTD | TTD1BI | 75 | 50approx | 50approx | 100 | 100 |
| XP-D/TTD | TTD2GL | < 25 | 10-40 | 10-40 | < 20 | 10 |
The extent of excision at 6hr as a percentage of normal cells.
Incision at photoproduct sites expressed as a percentage of normal cells.
Unscheduled DNA synthesis as a percentage of normal cells measured during the first 2-4hr after irradiation.
The extent of excision at 24hr as a percentage of normal cells.
The resistance to UV measured by colony formation expressed as a percentage of normal cells.
This cell line is a revertant of an XP-A cell line, XP12RO, created by mutagenesis, and contains a missense mutation (an arginine to glycine change) in the gene at the site of the original chain terminating mutation.
From: Chapter 15, Ultraviolet Radiation Carcinogenesis
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