Figure 5.3. Schematic representation of interactions between tumor suppressor gene products and proteins encoded by DNA tumor viruses.

Figure 5.3

Schematic representation of interactions between tumor suppressor gene products and proteins encoded by DNA tumor viruses. Large T antigen from polyomaviruses [such as simian virus 40 (SV40)] binds both the retinoblastoma (pRb) and p53 proteins. For the adenoviruses and the high-risk human papillomaviruses (HPV types 16 and 18), different viral protein products complex with pRb and p53. A cellular protein known as E6-associated protein (E6-AP) cooperates with the HPV E6 protein to complex and degrade p53. (Modified with permission of Science from Werness BA, Levine AJ, Howley PM: Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248: 76, 1990.). [Figure represents an updated version of Figure 6.3 from Fearon ER, Vogelstein B. Tumor suppressor and DNA repair gene defects in human cancer. In: Holland JF, Frei E, Bast RC, Kufe DW, Morton DL, Weichselbaum RR, Eds. Cancer Medicine 4th Edition. Williams & Wilkins, Baltimore, MD 1997; pp. 97-117.].

From: Chapter 5, Tumor Suppressor Gene Defects in Human Cancer

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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