Table 85.2The Clinical Syndromes

Clinical syndromeTumor typeSiteHormone(s)
Flushing/diarrhea/wheezingCarcinoidMid foregutSerotonin, substance P
Pancreas/foregutNKA, TCT, PP,
Adrenal medullaCGRP, VIP
Ulcer diseaseGastrinomaPancreas (85%) Duodenum (15%)Gastrin
HypoglycemiaInsulinoma SarcomasPancreas/uterusInsulin/TNF
HepatomaRetroperitoneal LiverIGF/BP
Dermatitis/dementiaGlucagonomaPancreasGlucagon
Diabetes/DVT
Diabetes/steatorrheaSomatostatinomaPancreasSomatostatin
Cholelithiasis/neurofibromatosisSomatostatinomaDuodenumSomatostatin
Silent/liver metsPPomaPancreasPP
AcromegalyGEPPancreasGH (GHRH)
CushingsGEPPancreasACTH/CRF
HypercalcemiaVIPomaPancreasVIP
GEPPancreasPTHrP
PigmentationGEPPancreasMSH

ACTH = adrenocorticotropic hormone, corticotropin; BP = binding protein; CGRP = calcitonin gene, related peptide; CRF = corticotropin releasing factor; DVT = deep venous thrombosis; GEP = gastroenteropancreatic; GH = growth hormone, somatotropin; GHRH = growth hormone-releasing hormone; IGF = insulin-like growth factor; MSH = melanocyte stimulating hormone; NKA = neurokinin A; PP = pancreatic polypeptide; PTHrP = parathyroid hormone related peptide; TCT = thyrocalcitonin; TNF = tumor necrosis factor; VIP = vasoactive intestinal peptide.

From: Chapter 85, Neoplasms of the Neuroendocrine System and Neoplasms of the Gastroenteropancreatic Endocrine System

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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