Table 13.2Candidate Genes in Hormone-Related Cancers

Cancer SiteProliferative HormoneRelevant Genes
BreastEstrogenCYP17, CYP19, HSD17B1, ER
ProgesteroneCYP17, PR, COMT
EndometriumEstrogenCYP17, HSD17B1, HSD17B2
OvaryFSH, ProgesteroneFSH, FSHR, HSD17B1, PR
ProstateTestosterone (Dihydrotestosterone)CYP17, HSD17B3, SRD5A2, AR

CYP17 = cytochrome p450 17, 20 lyase; CYP19 = aromatase; HSD17 B1 = 17 β-hydroxysteroid dehydrogenase type I; ER = estrogen receptor; PR = progesterone receptor; FSH, FSHR = follicle stimulating hormone and receptor; 5RD5A2 = 5-alpha reductase, type II.

From: Chapter 13, Hormones and the Etiology of Cancer

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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