TransmitteraCellbCriteriacCommentsReferences
AChALN(2)2J. Duerr (pers. comm.)
AS(11)2,3,4Stretton et al. (1978); Johnson and Stretton (1985); J. Duerr (pers. comm.)
CA(4)4maleC. Johnson (pers. comm.)
DA(9)2,3,4Stretton et al. (1978); Johnson and Stretton (1985); J. Duerr (pers. comm.)
DB(7)2,3,4Stretton et al. (1978); Johnson and Stretton (1985); J. Duerr (pers. comm.)
HSN(2)2,5staining weak and variable; reduction of ACh synthesis does not functionWeinshenker et al. (1995); J. Duerr (pers. comm.)
M12J. Duerr (pers. comm.)
M2(2)2J. Duerr (pers. comm.)
M4 2staining variable; reduction of ACh synthesis does not functionJ. Duerr; L. Avery (both pers. comm.)
M52J. Duerr (pers. comm.)
MC3,5staining weak or nonexistentRaizen et al. (1995); J. Duerr (pers. comm.)
PLN(2)2J. Duerr (pers. comm.)
SAA(4)2J. Duerr (pers. comm.)
SAB(3)2J. Duerr (pers. comm.)
SDQ(2)2J. Duerr (pers. comm.)
SIA(4)2J. Duerr (pers. comm.)
SIB(4)2J. Duerr (pers. comm.)
SMB(4)2J. Duerr (pers. comm.)
SMD(4)2J. Duerr (pers. comm.)
VA(12)2,3J. Duerr (pers. comm.)
VB(11)2,3J. Duerr (pers. comm.)
VC(6)2J. Duerr (pers. comm.)
GABA AVL 1A,2,3McIntire et al. (1993b); Y. Jin (pers. comm.)
DD(6)1A,1B, 2,3,4Stretton et al. (1978); Johnson and Stretton (1987); McIntire et al. (1993b); Y. Jin (pers. comm.)
DVB 1A,1B, 2,3,4Guastella et al. (1991); McIntire et al. (1993b); Y. Jin (pers. comm.)
RIS1A,2McIntire et al. (1993b); Y. Jin (pers. comm.)
RME(4)1A,1B, 2,3,4Guastella et al. (1991); McIntire et al. (1993b); Y. Jin (pers. comm.)
VD(13)1A,1B, 2,3,4Stretton et al. (1978); Johnson and Stretton (1987); McIntire et al. (1993b); Y. Jin (pers. comm.)
DAADE(2)1A,3Sulston et al. (1975); B. Sawin (pers. comm.)
CEP(4)1A,3Sulston et al. (1975); B. Sawin (pers. comm.)
PDE(2)1A,3Sulston et al. (1975); B. Sawin (pers. comm.)
R5A(2)1Amale tail Sulston and Horvitz (1977)
R7A(2)1Amale tail Sulston and Horvitz (1977)
R9A(2)1Amale tail Sulston and Horvitz (1977)
5-HTADF(2)1AG. Garriga and C. Bargmann (pers. comm.)
CA(4)1Amale; CA1-CA4 only; staining weak in C.elegans; no staining in AscarisLoer and Kenyon (1993); Johnson et al. (1996)
CP(6)1A,1B, 3male; CP1-CP6 only; very strong stainingLoer and Kenyon (1993); Johnson et al. (1996)
HSN(2)1A,5strong staining; loss of 5-HT in cat-4 or bas-1 does not prevent functionDesai et al. (1988); Weinshenker et al. (1995)
NSM(2)1A,1Bvery strong stainingHorvitz et al. (1982); Johnson et al. (1996)
RIG(2)1Amight be AIM or AIY instead of RIGJ. Kaplan; B. Sawin (both pers. comm.)
RIH 1AG. Garriga and J. Thomas (pers. comm.)
R1A/B(2)1Amale tail Loer and Kenyon (1993)
R3A/B(2)1Amale tail Loer and Kenyon (1993)
R9A/B(2)1Amale tail Loer and Kenyon (1993)
VC(2)1AVC4 and VC5 onlyG. Garriga (pers. comm.)
GLUASH(2)3Hart et al. (1995); Maricq et al. (1995)
M3 3,5Avery and Thomas (this volume)
a

Neurotransmitter abbreviations: (ACh) Acetylcholine, (GABA) γ-aminobutyric acid; (DA) dopamine; (5-HT) serotonin; (GLU) glutamate.

b

If a cell type includes more than one cell, the number of cells in the class is indicated in parentheses.

c

Criteria:

(1A)

The transmitter is present in the C. elegans cell, identified by immunostaining (for GABA and 5-HT) and/or by formaldehyde-induced fluorescence (for DA and 5-HT).

(1B)

The transmitter is present in the comparable cell in Ascaris, identified by immunostaining for GABA or 5-HT.

(2)

The biosynthetic enzyme is present in the cell, determined by antibodies to choline acetyltransferase or by reporter gene expression of unc-25.

(3)

Supported by mutant data, i.e., loss of transmitter (in cha−1, unc-25, or cat) or loss of receptor (in postsynaptic partner) is associated with loss of cell function.

(4)

Supported by physiological, pharmacological, and/or biochemical studies of the homologous cell(s) from Ascaris.

(5)

Supported by other data, such as C. elegans electrophysiology or pharmacology studies.

From: Appendix 2 Neurotransmitter Assignments for Specific Neurons

Cover of C. elegans II
C. elegans II. 2nd edition.
Riddle DL, Blumenthal T, Meyer BJ, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.
Copyright © 1997, Cold Spring Harbor Laboratory Press.

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