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Riddle DL, Blumenthal T, Meyer BJ, et al., editors. C. elegans II. 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.

Cover of C. elegans II

C. elegans II. 2nd edition.

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Section IXTranslation Initiation and Termination Signals

Initiation of translation in metazoans always occurs at an AUG codon. In addition to these three nucleotides, there appears to be information content in the preceding nucleotides, where the consensus is (A/G)CCAUG in vertebrates. In 211 genes included in the survey reported here, there is also a consensus in the nucleotides preceding the AUG, but it is quite different from the vertebrate consensus. C. elegans genes prefer A residues at each of the four positions preceding the AUG (Fig. 9). This is similar to the consensus proposed for ciliates and yeast, AAAAUG (Cigan and Donahue 1987; Brunk and Sadler 1990).

Figure 9. Translation initiation and termination sequences.

Figure 9

Translation initiation and termination sequences. The frequency (percent) of each nucleotide at each position with respect to the translation initiation codon, AUG (above) or translation termination codons (more...)

There are also consensus sequences preceding and following the stop codon in C. elegans. The consensus is A/U, C/U−stop codon−A, U. Furthermore, not all termination codons are utilized with equal frequency: 61% are UAA, 17% UAG, and 22% UGA (Fig. 9).

Copyright © 1997, Cold Spring Harbor Laboratory Press.
Bookshelf ID: NBK20150

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