Figure 15. A, Section from the mid-LAD coronary artery in a 58-year-old male.
Figure 15. A, Section from the mid-LAD coronary artery in a 58-year-old male.
Figure 15. A, Section from the mid-LAD coronary artery in a 58-year-old male.
Figure 15. A, Section from the mid-LAD coronary artery in a 58-year-old male.

Figure 15

A, Section from the mid-LAD coronary artery in a 58-year-old male. A large circumferential calcified plaque (arrows) surrounds a large lipid rich necrotic core (asterisks). H & E stain. Magnification x11.5. B, Small calcified plaque (arrows) in the distal RCA of a 58-year-old male, showing a small structureless central core (asterisk). H & E stain. C, Large necrotic central core with small rim of calcification (solid arrows). Note the irregular, moth-eaten border (open arrows) that faces the core. MSB stain. D, Small calcium deposit at the rim of a necrotic core (solid arrows), immunostained for osteopontin (brown reaction product), showing that these calcium deposits stain intensely for osteopontin. Note that the loose fragment (open arrow) also stains positive for osteopontin.

From: Chapter 5, Calcification: A Physiologic Defense

Cover of Inflammatory Atherosclerosis
Inflammatory Atherosclerosis: Characteristics of the Injurious Agent.
Frink RJ.
Sacramento (CA): Heart Research Foundation; 2002.
Copyright © 2002, Richard J Frink.

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