Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes.

Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges, paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device.

Contents

• Series Preface
• Preface
• Acknowledgments
• Editor
• Contributors
• Part I
  • 1. Overview of Wound Healing in Different Tissue Types
    John D. Stroncek and W. Monty Reichert.
• Part II
  • 2. Signal Considerations for Chronically Implanted Electrodes for Brain Interfacing
    Warren M. Grill.
  • 3. Thermal Considerations for the Design of an Implanted Cortical Brain–Machine Interface (BMI)
    Patrick D. Wolf.
• Part III
  • 4. In Vitro Models for Neuroelectrodes: A Paradigm for Studying Tissue–Materials Interactions in the Brain
    Vadim Polikov, Michelle Block, Cen Zhang, W. Monty Reichert, and J. S. Hong.
  • 5. In Vivo Solute Diffusivity in Brain Tissue Surrounding Indwelling Neural Implants
    Michael J. Bridge and Patrick A. Tresco.
• Part IV
  • 6. A Molecular Perspective on Understanding and Modulating the Performance of Chronic Central Nervous System (CNS) Recording Electrodes
    Wei He and Ravi V. Bellamkonda.
  • 7. Soft, Fuzzy, and Bioactive Conducting Polymers for Improving the Chronic Performance of Neural Prosthetic Devices
    Dong-Hwan Kim, Sarah Richardson-Burns, Laura Povlich, Mohammad Reza Abidian, Sarah Spanninga, Jeffrey L. Hendricks, and David C. Martin.
  • 8. Strategies for Regeneration and Repair in the Injured Central Nervous System
    Molly S. Shoichet, Ciara C. Tate, M. Douglas Baumann, and Michelle C. LaPlaca.

Series editors: Miguel AL Nicolelis and Sidney A Simon

This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use.