FIGURE 32.1. Domain structures of the known Siglecs in humans and mice.

FIGURE 32.1

Domain structures of the known Siglecs in humans and mice. There are two subgroups of Siglecs: One group contains sialoadhesin (Siglec-1), CD22 (Siglec-2), MAG (Siglec-4), and Siglec-15, and the other group contains CD33-related Siglecs. In humans, Siglec-12 has lost its arginine residue required for sialic acid binding and Siglec-13 is deleted. The plus sign indicates the presence of a charged residue in the transmembrane domain, which has been shown to interact with the immunoreceptor tyrosine-based activatory motif (ITAM)-containing adaptor proteins DAP12 and DAP10. (ITIM) Immunoreceptor tyrosine-based inhibitory motif.

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From: Chapter 32, I-type Lectins

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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