FIGURE 18.5. Protein phosphatase 1 catalytic subunit (PP1c), a key enzyme that removes O-phosphate residues from many important regulatory proteins, exists in a complex with O-GlcNAc transferase, which attaches O-GlcNAc.

FIGURE 18.5

Protein phosphatase 1 catalytic subunit (PP1c), a key enzyme that removes O-phosphate residues from many important regulatory proteins, exists in a complex with O-GlcNAc transferase, which attaches O-GlcNAc. This suggests that the same enzyme complex both removes phosphate and attaches O-GlcNAc, perhaps without detaching from the substrate. (TPR) Tetratricopeptide repeat. (Redrawn, with permission, from Slawson C., Housley M.P., and Hart G.W. 2006. J. Cell. Biochem. 97: 71–83.)

From: Chapter 18, The O-GlcNAc Modification

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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