TABLE 5-1Publications Reporting a Single Health Outcome in New Populations

CitationStudy DesignExposure Measure(s) Having ResultsHealth Outcome(s) ReportedStudy Population
Studies of Vietnam Veterans
Occupational Studies
Kamel et al., 2012Case-control (nested)Pesticides, herbicides, 2,4-D, 2,4,5-T, dicambaALSAHS
Environmental Studies
Buck Louis et al., 2011Cross-sectionalanti-estrogenic PCBs (correspond to dl PCBs)Menstrual cyclesWomen without reproductive problems
Goncharov et al., 2011Cross-sectionalPCB subsets (mono-ortho TEQ, estrogenic)HypertensionAnniston (AL) Community Health Survey
Kezios et al., 2012Pregnancy cohortdl PCB 118Birth weight, gestational ageCalifornia Child Health and Development Studies, University of California, Berkeley
Leijs et al., 2012Prospective cohortPrenatal TEQs for dioxin/furans, dl PCBsSons' thyroid metabolism at pubertyMother–baby pairs from Netherlands (followup on cohort of Ilsen et al., 1996)
Miyashita et al., 2011CohortTotal dioxins, furans, dl PCBs (non-ortho and mono-ortho) in maternal blood (3rd trimester)Immune function in offspring (infections [otitis media], allergies [asthma, eczema, food allergies])Hokkaido Study on Environment and Children's Health Japanese mothers and infants examined at birth and at 18 months of age
Nishijo et al., 2012Birth cohortTEQs PCDD/Fs in breast milk 1 mo after birthInfant growth (birth, 1 mo, 4 mo), neurodevelopmentMother–infant pairs from contaminated area of Vietnam
Virtanen et al., 2012; Krysiak-Baltyn et al., 2012Case-control (nested)TEQs for dioxins, furans, PCBs in placenta, individual results on comprehensive list of dl-PCBs; in breast milkCongenital cryptorchidism; Seeking pattern of congeners distinguishing cases with cryptorchidism form controls [results of interest in Virtanen et al., 2012]Danish-Finnish Prospective Cohort: boys examined at birth and 3 months of age
Case-Control Studies
Band et al., 2011Case-control2,4-D, MCPA, dicambaProstate cancerBritish Columbia farmers
Bonefeld-Jorgensen et al., 2011Case-controlSum dl PCBs, AHR-TEQsBreast cancerInuit women from Greenland sampled 2000–2003
Cai et al., 2011Case-controlDioxins, furans, all dl-PCBs, TEQ in peritoneal fluid and serumEndometriosisJapanese women undergoing diagnostic laparoscopy for infertility enrolled from October 2004 to March 2007
Gallagher et al., 2011Case-controldl PCBs 118, 156, total dl PCBs in serumMelanomaStudy participants were recruited using a population-based British Columbia Cancer Registry
Lv et al., 2011Case-controlOccupational exposure to herbicides [marginal]MDSShanghai, China
Postuma et al., 2012Case-controlOccupational herbicide exposure, non-occupational only as specific as “pesticides” [marginal]REM sleep behavior disorder (prognostic sign of PD and dementia)Cases drawn from seven centers
Rollison et al., 2011Case-controlPesticides, herbicides (case-control comparison shown for telomere length and then telomere length within MDS cases compared on basis of pesticide use) [marginal]MDS (indirect evidence)Newly diagnosed MDS cases in Florida
Rugbjerg et al., 2011Case-controlSelf-reported pesticide exposure (2,4-D & 2,4,5-T in “herbicides,” “pesticides with known neurotoxicity” classes) [marginal]PDBritish Columbia PD cases and controls
Slater et al., 2011Case-controlHousehold chemicals (specificity to level of “herbicides”) [marginal]Leukemia in infantsInfants diagnosed with acute leukemia at < 1 year of age at Children's Oncology Group institutions in US and Canada
Wong et al., 2010Case-controlPrimarily job title, but also “herbicides” [marginal]NHLNewly diagnosed patients in Shanghai
Zakerinia et al., 2012Case-controlPesticides [for individual types]; Herbicides for all lymphomasLymphoid neoplasms (HL, NHL, multiple myeloma, T-cell)Diagnoses at Nemazee Hospital, Shiraz, Iran

NOTE: 2,4-D, 2,4-dichlorophenoxyacetic acid; 2,4,5-T, 2,4,5-trichlorophenoxyacetic acid; AHR, aryl hydrocarbon receptor; AHS, Agricultural Health Study; ALS, amyotrophic lateral sclerosis; dl, dioxin-like; HL, Hodgkin lymphoma; MCPA, 2-methyl-4-chlorophenoxyacetic acid; MDS, myelodysplastic syndrome; NHL, non-Hodgkin lymphoma; PCB, polychlorinated biphenyl; PCDD, polychlorinated dibenzo-p-dioxin; PCDF, polychlorinated dibenzofuran; REM, rapid eye movement; TEQ, total toxic equivalent.

From: 5, Epidemiologic Studies: Compendium of New Publications

Cover of Veterans and Agent Orange
Veterans and Agent Orange: Update 2012.
Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update); Board on the Health of Select Populations; Institute of Medicine.
Washington (DC): National Academies Press (US); 2014 Mar 6.
Copyright 2014 by the National Academy of Sciences. All rights reserved.

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