FIGURE 35.2. Crystal structure of the antithrombin-pentasaccharide complex (from Protein Data Bank).

FIGURE 35.2

Crystal structure of the antithrombin-pentasaccharide complex (from Protein Data Bank). (A,D) α-Helices that make contact with heparin; (RCL) the reactive center loop that inactivates thrombin and Factor X; (F) another α-helix in the protein. (Lower panel) Interactions between key amino acid residues and individual elements in the pentasaccharide. (Solid lines) Electrostatic interactions between positively charged residues and sulfate groups; (broken lines) hydrogen bonds; (alternately broken and solid line) bridging water molecule.

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From: Chapter 35, Proteins that Bind Sulfated Glycosaminoglycans

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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