Figure 20. Structure of the HIV-1 Rev response element and Rev-binding peptide.

Figure 20

Structure of the HIV-1 Rev response element and Rev-binding peptide. (Top) Predicted secondary structure of the RRE, showing the location of the primary Rev-binding site, indicated in color. Arrows indicate G residues involved in G:G base pairing. (Bottom) HIV-1 Rev peptide–RRE RNA complex as determined by NMR studies (Battiste et al. 1996). The peptide binds in a widened major groove that requires a kink in the phosphate backbone and a bulged nucleotide. Peptide (red) with amino acids that have a role in RNA binding as determined by genetic analyses highlighted (yellow, orange); RNA (blue) with sites of protein contact to backbone highlighted (blue balls) as mapped by ethylation interference; invariant nucleotides from in vitro selection studies (green).

From: Processing of Retroviral RNA

Cover of Retroviruses
Retroviruses.
Coffin JM, Hughes SH, Varmus HE, editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.
Copyright © 1997, Cold Spring Harbor Laboratory Press.

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