Figure 3. Proto-oncogenes can be activated in multiple ways.

Figure 3

Proto-oncogenes can be activated in multiple ways. (Top) The c-myc locus and its protein product encoded by exons 2 and 3; (A) activation via oncogene capture as illustrated by the genome and fusion protein product of MC29 virus, one of several retroviruses that have recombined with c-myc sequences; (B) insertion of a provirus into the c-myc locus as illustrated by the ALV provirus between the first and second exons of c-myc in the same transcriptional orientation as commonly found in bursal lymphomas; (C) activation following translocation of c-myc exons 2 and 3 into the vicinity of the switch (S) region of the immunoglobulin heavy-chain gene locus as observed in some cases of Burkitt's lymphoma. The asterisk indicates the translocation break point. The translocation illustrated is one of several possible configurations.

From: Oncogenesis

Cover of Retroviruses
Coffin JM, Hughes SH, Varmus HE, editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.
Copyright © 1997, Cold Spring Harbor Laboratory Press.

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