Figure 5. Retroviral transformation and oncogene transduction.

Figure 5

Retroviral transformation and oncogene transduction. From the top right: Infection of a cell with a retrovirus that contains only viral genes can occasionally initiate tumor formation by insertion of the provirus next to a protooncogene. Recombination during subsequent infection can lead to the incorporation of the cell-derived oncogene. Cells infected with virus with only the oncogene-containing genome become transformed nonproducer cells from which transforming virus can be rescued by superinfection with a replication-competent, nontransforming helper virus.

From: The Place of Retroviruses in Biology

Cover of Retroviruses
Retroviruses.
Coffin JM, Hughes SH, Varmus HE, editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.
Copyright © 1997, Cold Spring Harbor Laboratory Press.

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