Table 1Pathologic Conditions Associated with AIDS

Primary infection
Mononucleosis-like syndrome:
fever, malaise, pharyngitis, lymphadenopathy, headache, arthralgias, diarrhea, maculopapular rash, meningoencephalitis
Clinical latency
Often none, but can include:
fatigue, mild weight loss, generalized lymphadenopathy, thrush, oral hairy leukoplakia, shingles
Clinical disease
200–500 CD4+ T cells/ml:
generalized lymphadenopathy
oral lesions (thrush, hairy leukoplakia, aphthous ulcers)
reactivation of herpes zoster (shingles)
thrombocytopenia
molluscum contagiosum
basal cell carcinomas of the skin
headache
condyloma acuminata
reactivation of latent Mycobacteria tuberculosis
Less than 200 CD4+ T cells/ml:
Protozoal infections:
Pneumocystis carinii, Toxoplasma gondii, Isospora belli, Cryptosporidia, Microsporidia
Bacterial infections:
Mycobacterium avium intracellulare, Treponema pallidum
Fungal infections:
Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum
Viral infections and malignancies:
cytomegalovirus (CMV)
recurrent bouts of oral or genital herpes simplex virus
lymphoma (mostly EBV, some HHV-8)
Kaposi's sarcoma (HHV-8)
anogenital carcinoma (HPV)
Neurological symptoms
aseptic meningitis
myelopathies such as vacuolar myelopathy
pure sensory ataxia, paresthesia/dysesthesia, peripheral neuropathies such as acute demyelinating polyneuropathy, mononeuritis multiplex, and distal symmetric polyneuropathy
myopathy
AIDS dementia complex
(Tindall and Cooper 1991; Fauci and Lane 1997)

From: Course of Infection with HIV and SIV

Cover of Retroviruses
Retroviruses.
Coffin JM, Hughes SH, Varmus HE, editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.
Copyright © 1997, Cold Spring Harbor Laboratory Press.

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