FIGURE 1.8. Biosynthesis, use, and turnover of a common monosaccharide.


Biosynthesis, use, and turnover of a common monosaccharide. This schematic shows the biosynthesis, fate, and turnover of galactose, a common monosaccharide constituent of animal glycans. Although small amounts of galactose can be taken up from the outside of the cell, most cellular galactose is either synthesized de novo from glucose or recycled from degradation of glycoconjugates in the lysosome. The figure is a simplified view of the generation of the UDP nucleotide sugar UDP-Gal, its equilibrium state with UDP-glucose, and its uptake and use in the Golgi apparatus for synthesis of new glycans. (Solid lines) Biochemical pathways; (dashed lines) pathways for the trafficking of membranes and glycans.

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From: Chapter 1, Historical Background and Overview

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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