FIGURE 1.7. Glycan-protein linkages reported in nature.


Glycan-protein linkages reported in nature. (Updated and redrawn, with permission of Oxford University Press, from Spiro R.G. 2002. Glycobiology. 12: 43R–56R.) Diagrammatic representation of the five distinct types of sugar-peptide bonds that have been identified in nature, to date. Monosaccharide abbreviations are as in Figure 1.5. In addition, (Ara) arabinose; (Rha) rhamnose; (FucNAc) N-acetylfucosamine (2-acetamido-2,6-dideoxy-D-galactose); (Bac) bacillosamine (2,4-diamino-2,4,6-trideoxy-D-glucose); (Pse) pseudaminic acid (5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-L-manno-nonulosonic acid); (Hyl) hydroxylysine; (Hyp) hydroxyproline; (C-term) carboxy-terminal amino acid residue. Glypiation is the process by which a glycosylphosphatidylinositol (GPI) anchor is added to a protein. For other details, including anomeric linkages, please see the Spiro (2002) review cited above.

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From: Chapter 1, Historical Background and Overview

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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