FIGURE 4.1. Biosynthesis and interconversion of monosaccharides.



(i) The asterisk indicating regulated steps in nucleotide sugar formation was incorrectly positioned at the glucosamine-6-PO4 acetyltransferase and should be located at the fructose-6-PO4 amidotransferase. (ii) N-acetylneuraminic-6-PO4 should be N-acetylneuraminic-9-PO4. (iii) ManNAc can be converted to Neu5Ac via Sialate:pyruvate lyase action as shown in the lower part of the figure. Readers should be aware that ManNAc can also be interconverted with GlcNAc under some conditions.

Biosynthesis and interconversion of monosaccharides. The relative contributions of each pathway under physiological conditions are unknown. (Rectangles) Donors; (ovals) monosaccharides; (asterisks) control points; (6PG) 6-phosphogluconate; (PEP) phosphoenolpyruvate; (KDN) 2-keto-3-deoxy-D-glycero-D-galactonononic acid; (Dol) dolichol.

Symbol Key: FIGURE 4.1. Biosynthesis and interconversion of monosaccharides.

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From: Chapter 4, Glycosylation Precursors

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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