FIGURE 24.5. Glycosphingolipid glycan diversity.

FIGURE 24.5

Glycosphingolipid glycan diversity. The arthroseries of glycosphingolipids are built by extension from a mactosylceramide core (Manβ1-4Glcβ-ceramide). Neutral arthroseries glycans are frequently modified by the addition of ethanolamine (orange ovals) on N-acetylglucosamine residues, forming a zwitterionic structure. The relationship between glycan extension and modification with ethanolamine is unknown. Acidic charge is imparted by the addition of glucuronic acid to nonreducing terminal galactose residues on neutral or zwitterionic cores. Extension of the GalNAc-terminated arthrotetraose by addition of galactose (shaded box) has been demonstrated in different developmental stages of two dipterans, the larvae of the greenbottle fly (Lucilia caesar) and the pupae of the blowfly (Calliphora vicina), but not in embryos of Drosophila.

Symbol Key: FIGURE 24.5. Glycosphingolipid glycan diversity.

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From: Chapter 24, Arthropoda

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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