FIGURE 34.3. Model of foot-and-mouth disease virus (FMDV) in complex with heparin trisaccharides.

FIGURE 34.3

Model of foot-and-mouth disease virus (FMDV) in complex with heparin trisaccharides. (a) A schematic depiction of the icosahedral capsid of FMDV. VP1–3 contribute to the external features of the capsid: (blue) VP1; (green) VP2; (red) VP3. The heparin-binding site is located in the center of a protomer derived from the uncleaved polyprotein (bold outline). (Redrawn, with permission, from Fry E.E., Lea S.M., Jackson T., et al. 1999. EMBO J. 18: 543–554, ©Macmillan Publishers Ltd.) (b) Ligand-binding site in serotype A1061. Viral proteins are depicted as a ribbon diagram with the same color coding as in a. The sugar residues of a heparin trisaccharide ligand is drawn as purple balls with sulfur atoms in yellow. (c) Sugar–protein interactions. Only protein side chains that interact directly are shown. Ligand bonds are drawn in purple and nonligand bonds in brown. Hydrogen bonds are depicted by olive-green, dashed lines. Nonligand residues involved in hydrophobic contacts are shown as red, fringed semicircles. Water molecules are red. Idu, Iduronic acid; Gcn, glucosamine residue. (b,c: Redrawn, with permission, from Fry E.E., Newman J.W., Curry S., et al. 2005. J. Gen. Virol. 86: 1909–1920.)

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From: Chapter 34, Microbial Lectins: Hemagglutinins, Adhesins, and Toxins

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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