| Vaccine | Adverse Event | Epidemiologic Assessment | Studies Contributing to the Epidemiologic Assessment | Mechanistic Assessment | Cases Contributing to the Mechanistic Assessment | Causality Conclusion |
|---|---|---|---|---|---|---|
| MMR | Measles Inclusion Body Encephalitis | Insufficient | None | Strong (measles; in individuals with demonstrated immunodeficiencies) | 1 | Convincingly Supportsa (in individuals with demonstrated immunodeficiencies) |
| Lacking (mumps or rubella) | None | |||||
| MMR | Encephalitis | Limited | 3 | Weak | 3 | Inadequate |
| MMR | Encephalopathy | Limited | 3 | Weak | 1 | Inadequate |
| MMR | Febrile Seizures | High (increase) | 7 | Intermediate | 12 | Convincingly Supports |
| MMR | Afebrile Seizures | Limited | 2 | Lacking | None | Inadequate |
| MMR | Meningitisb | Moderate (null) | 3 | Weak (mumps) | 4 | Inadequate |
| Lacking (measles or rubella) | None | |||||
| MMR | Ataxia | Insufficient | None | Weak (measles or mumps) | 1 | Inadequate |
| Lacking (rubella) | None | |||||
| MMR | Autism | High (null) | 4 | Lacking | None | Favors Rejection |
| MMR | Acute Disseminated Encephalomyelitis | Insufficient | None | Weak | None | Inadequate |
| MMR | Transverse Myelitis | Insufficient | None | Weak | 3 | Inadequate |
| MMR | Optic Neuritisb | Limited | 1 | Weak | 2 | Inadequate |
| MMR | Neuromyelitis Opticab | Insufficient | None | Weak (rubella) | 1 | Inadequate |
| Lacking (measles or mumps) | None | |||||
| MMR | Multiple Sclerosis Onset in Adults | Limited | 2 | Lacking | None | Inadequate |
| MMR | Multiple Sclerosis Onset in Children | Limited | 1 | Lacking | None | Inadequate |
| MMR | Guillain-Barré Syndrome | Insufficient | None | Weak | None | Inadequate |
| MMR | Chronic Inflammatory Disseminated Polyneuropathy | Insufficient | None | Lacking | None | Inadequate |
| MMR | Opsoclonus Myoclonus Syndrome | Insufficient | None | Lacking | None | Inadequate |
| MMR | Brachial Neuritis | Insufficient | None | Lacking | None | Inadequate |
| MMR | Anaphylaxis | Insufficient | None | Strong | 43c | Convincingly Supports |
| MMR | Transient Arthralgia in Women | Moderate (increase) (rubella) | 4 | Intermediate (rubella) | 13 | Favors Acceptanced |
| Insufficient (measles or mumps) | None | Lacking (measles or mumps) | None | |||
| MMR | Transient Arthralgia in Children | Moderate (increase) | 7 | Weak (rubella) | None | Favors Acceptance |
| Lacking (measles or mumps) | None | |||||
| MMR | Chronic Arthralgia in Women | Limited (rubella) | 2 | Low-Intermediate (rubella) | 4 | Inadequate |
| Insufficient (measles or mumps) | None | Lacking (measles or mumps) | None | |||
| MMR | Chronic Arthritis in Women | Limited (rubella) | 2 | Low-Intermediate (rubella) | 5 | Inadequate |
| Insufficient (measles or mumps) | None | Lacking (measles or mumps) | None | |||
| MMR | Chronic Arthropathy in Children | Insufficient | None | Weak (rubella) | 2 | Inadequate |
| Lacking (measles or mumps) | None | |||||
| MMR | Arthropathy in Men | Limited | 2 | Weak (rubella) | None | Inadequate |
| Lacking (measles or mumps) | None | |||||
| MMR | Type 1 Diabetes | High (null) | 5 | Lacking | None | Favors Rejection |
| MMR | Hepatitis | Insufficient | None | Weak | None | Inadequate |
| MMR | Chronic Fatigue Syndrome | Insufficient | None | Lacking | None | Inadequate |
| MMR | Fibromyalgia | Insufficient | None | Lacking | None | Inadequate |
| MMR | Hearing Loss | Insufficient | None | Low-Intermediate (measles or mumps) | 8 | Inadequate |
| Lacking (rubella) | None |
The committee attributes causation to the measles component of the vaccine.
Although not originally charged to the committee by the sponsor, the committee considered this adverse event in its review of the literature.
Some cases were from passive surveillance systems; however, it was not possible to know how many represented unique cases or were reported elsewhere.
The committee attributes causation to the rubella component of the vaccine.
From: 4, Measles, Mumps, and Rubella Vaccine
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